Wednesday, December 28, 2011

JosieBrownCA: Wishful thinking? RT @maryheston 3 reasons Microsoft's Bing will gain ground against Google in '12 http://t.co/fgwIVCtf #socialnetworking

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Wishful thinking? RT @maryheston 3 reasons Microsoft's Bing will gain ground against Google in '12 sgoti.ws/rLcv7H #socialnetworking JosieBrownCA

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Source: http://twitter.com/JosieBrownCA/statuses/151517693835608065

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China blames 54 officials for bullet train crash

(AP) ? A long-awaited government report said design flaws and sloppy management caused a bullet train crash in July that killed 40 people and triggered a public outcry over the dangers of China's showcase transportation system.

A former railway minister was among 54 officials found responsible for the crash, a Cabinet statement said Wednesday. Several were ordered dismissed from Communist Party posts but there was no word of possible criminal penalties.

The crash report was highly anticipated by the public. The disaster near the southern city of Wenzhou also injured 177 people and had triggered a public outcry over the high cost and dangers of the bullet train system, a prestige project that once enjoyed lofty status on a level with the country's manned space program.

Regulations had required the report to be released by Nov. 20. When that date passed, the government offered little explanation, drawing renewed criticism by state media, which have been unusually skeptical about the handling of the accident and the investigation.

The Cabinet statement cited "serious design flaws and major safety risks" and what it said were a string of errors in equipment procurement and management. It also criticized the Railways Ministry's rescue efforts.

The report affirmed earlier government statements that a lightning strike caused one bullet train to stall and then a sensor failure and missteps by train controllers allowed a second train to keep moving on the same track and slam into it.

Those singled out for blame included former Minister of Railways Liu Zhijun, a bullet train booster who was detained in February amid a graft investigation. Also criticized was the general manager of the company that manufactured the signal, who died of a heart attack while talking to investigators in August.

The decision to assign blame to one figure who already has been jailed and another who is dead, along with mid-level managers who have been fired, suggests any additional political fallout will be limited.

Several officials including a former Communist Party secretary of the Shanghai Railway Bureau were ordered dismissed from their party posts, a penalty that is likely to end their career advancement. Others received official reprimands but there was no mention of possible criminal charges.

The bullet train, based on German and Japanese systems, is one facet of far-reaching government technology ambitions that call for developing a civilian jetliner, a Chinese mobile phone standard and advances in areas from nuclear power to genetics.

The bullet train system quickly grew to be the world's biggest but has suffered embarrassing setbacks. After the Wenzhou crash, 54 trains used on the Beijing-to-Shanghai line were recalled for repairs following delays caused by equipment failures.

Critics complain authorities have spent too much on high-speed lines while failing to invest enough in expanding cheaper, slower routes to serve China's poor majority.

Beijing is rapidly expanding China's 56,000-mile (91,000-kilometer) rail network, which is overloaded with passengers and cargo. But it has scaled back plans amid concern about whether the railway ministry can repay its mounting debts.

On Friday, the current railways minister, Sheng Guangzu, announced railway construction spending next year will be cut to about 400 billion yuan ($65 billion), down from this year's projected 469 billion yuan ($75 billion).

A failure to expand rail capacity could choke economic growth because exporters away from China's coast rely on rail to get goods to ports.

The rail ministry's reported debt is 2 trillion yuan ($300 billion). Analysts say its revenues are insufficient to repay that. That has prompted concern the ministry might need to be bailed out by Chinese taxpayers.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-12-28-AS-China-Bullet-Train-Crash/id-747d4691f025467b96a469e80d1365f3

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Tuesday, December 27, 2011

Arkansas Wedding Dresses: Big Sales at Six Bridal Boutiques

Image by Shutterstock.com

There are six wedding dress sales happening now in Arkansas - dresses as low as $99 - so make your appointments ASAP.

For all you brides-to-be who are strapped for cash after spending too much on others for Christmas, here's a belated present: Big sales on wedding dresses at six Arkansas bridal boutiques.

Danielle's Bridal in Clarksville: Wedding dresses are marked down as low as $99 during a winter sale going on through Jan. 14.?All gowns are on sale, including new gowns.?For more info click here.?To make an appointment call (479) 754-5885.

Always & Forever in Fort Smith: Check out its semi-annual sample sale, starting today (Dec. 26). For info click here, call (479) 646-1997 or e-mail info@alwaysforeverbridal.com.

Proposals Boutique in Little Rock: A wedding gown sample sale, running through Jan. 31, offers prices from 30-75 percent off. To learn more click here or call (501) 661-4696.

Low's Bridal & Formal in Brinkley: Low's is having its semi-annual half-price sale through Jan. 28 with couture gowns at 65 percent to 75 percent off.?Call (870) 734-3244 to schedule an appointment. For more information click here.

Jessica's Bridal & Formal in Bay (near Jonesboro): Wedding gowns will be as much as 75 percent off, making some as afforadable as $99. For more info click here or call (870) 781-3334.

MaRu in Pine Bluff: The store, which is closing, is selling its collection of 250 designer wedding gowns (sizes 4-24) off the rack at 40 percent off through the middle of January.?For more info click here or e-mail owner Betty Higman at BHigman1@ATT.net.

Source: http://www.inarkansas.com/28419/arkansas-wedding-dresses-big-sales-at-six-bridal-boutiques

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Largest protest since collapse of Soviet Union rocks Russia

Simon Shuster
London Independent
December 26, 2011

Russia?s leadership was forced to defend its legitimacy yesterday after about 100,000 demonstrators rallied in central Moscow to demand democratic reform and fair elections in the largest wave of popular dissent since the fall of the Soviet Union.

The rally on Moscow?s Sakharov Avenue on Saturday was the fourth and by far the biggest of the mass demonstrations provoked by the parliamentary vote held on 4 December. The ruling United Russia party, led by the Prime Minister, Vladimir Putin, held on to a slim majority in parliament in those elections, but the results have been tainted by claims of wholesale fraud.

The demonstrators stood for hours in sub-zero weather on Saturday listening to a line-up of speakers as diverse as the crowd itself, including TV celebrities, writers, musicians, politicians, scientists and a jailed dissident whose video message was broadcast on a giant screen beside the stage.

?The people are waking up,? said Sergei Udaltsov, the leader of the Left Front opposition group who was arrested on the day of the elections as he heading to a rally. ?The people have stopped putting up with this humiliating regime.?

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Source: http://www.infowars.com/largest-protest-since-collapse-of-soviet-union-rocks-russia/

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Monday, December 26, 2011

How To Install/Flash Android 4.0.3 Ice Cream Sandwich MIUI Alpha ROM On Galaxy N...

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Sudan army kills leader of main Darfur rebel group (AP)

KHARTOUM, Sudan ? The Sudanese army said it killed the leader of the main Darfur rebel group in fighting Sunday and touted his death as a key victory.

The army said Khalil Ibrahim, who led the Darfur-based Justice and Equality Movement, or JEM, was killed during a military offensive in North Kordofan state to retaliate for a deadly rebel attack there on Saturday. JEM is the most organized and effective military force in Darfur, the western region torn by conflict since 2003. JEM did not join a peace deal signed last year between other Darfur rebel groups and Sudanese President Omar al-Bashir's government in Khartoum.

JEM representatives could not immediately be reached for comment. But if Ibrahim's death is confirmed, it would be a serious blow to JEM, which has on several occasions threatened to bring down al-Bashir's regime in Khartoum by advancing toward the capital.

Darfur has been in turmoil since 2003, when ethnic African rebels accusing the Arab-dominated Sudanese government of discrimination took up arms against it. The Khartoum government is accused of retaliating by unleashing Arab militias on civilians ? a charge the government denies. The conflict has tapered off since 2009, but the U.N. estimates 300,000 people died and 2.7 million have been displaced. The International Criminal Court in the Hague has issued an international arrest warrant for al-Bashir for his alleged role in crimes against humanity in Darfur.

An army statement carried by Sudan's official SUNA news agency said Ibrahim and several associates were killed in Wad Banda, about 440 miles (700 kilometers) west of Khartoum in the North Kordofan region, which borders Darfur.

"The army cut all paths for the group as it was retreating and trying to cross into South Sudan to reorganize it forces," said Sudanese army spokesman Col. Sawarmy Khaled. "Our gallant armed forces were able to kill rebel Khalil Ibrahim along with some of his associates."

South Sudan seceded from the north in July to become the world's newest nation.

Fighting in Wad Banda had flared up in the past few days. On Saturday, the Sudanese army said Darfur rebels attacked three locations in neighboring North Kordofan, killing an unspecified number of civilians.

JEM has not claimed responsibility for the attack. However, in a dramatic push in 2008, hundreds of JEM fighters drove through the remote western region and attacked Khartoum's western outskirts. More recently, JEM spread its armed presence from Darfur into North Kordofan.

Ibrahim is believed to have recently returned to Sudan after years in exile in neighboring Libya, where he enjoyed the patronage of Moammar Gadhafi before he was ousted and killed in October at the hands of revolutionary fighters.

Ibrahim once served in al-Bashir's government before joining the rebellion. He refused to join a peace agreement signed in Qatar and backed by the African Union that was meant to provide a basis for a cease-fire, power sharing, equal distribution of wealth and compensation for displaced people.

"He completely refused to come to the negotiating table, he never joined the peace talks," Ismail el-Haj Musa, Sudanese deputy speaker of the council of states, told the pan-Arab Al-Jazeera TV on Sunday. "He committed acts against the state."

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111225/ap_on_re_mi_ea/ml_sudan

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Ghana President Pays $165,000 Parking Charges on Falcon 900EX in USA.

The Ghana presidential jet ?Falcon 900EX Easy? during the 28-days holiday stay by the president of Ghana John Evan Atta Mills, at New York and other parts in USA accrued $165,420 charges for airport or aerodrome facilities and air route navigation facilities within the period of Nov & Dec 2011.

It's a known fact that the charges for landing an aircraft other than airship at Government Airports/Aerodromes, parking and housing charges in USA is quite exorbitant. Many people have questioned the sense in flying a presidential jet to America, flying around and parking for over 28 days for annual holidays other than a US government invites who could receive some VIP discount for foreign government officials. One could have thought an annual holiday without a large family should have equally patronised any reputable commercial flights for such occasion.

According to the Global Business Travel Journal ?it is unfathomable for a president from a third world country (Ghana) which depends largely on donors for budget support to embark on annual holidays to America for such period using the country's Presidential Jet, knowing that the parking charges for each 24 hours period or part thereof shall be 35% of the landing charges when parking period exceeds 6 hours?.

Though, others could also argue from many angles that the Falcon 900EX which flies 4,550 nautical miles nonstop, as the fastest in its class has all the necessary features for the comfortability and security of president. With its classic trijet engine design, the 900EX can use small airports at high altitudes, even on hot days. It's the most versatile aircraft and also one of the safest given its ability to fly slower on approach than its twinjet competitors.

It is also unquestionable that the state-of-the-art flight deck of Falcon 900EX offers pilots an uncompromising capability to monitor and control the progression of the flight while the spacious, custom-crafted cabin offers passengers the intransigent capability to perform at peak levels while en route.

But since all airport flight charges depend on the Maximum Land Weight (MLW) and Maximum Take-Off Weight (MTOW), one should taken into consideration the length of stay in USA and the weight of Ghana Presidential Jet with the Take-Off Weight of 49,000bl (22,226Kg) and the Landing Weight of 44,500lb (20,185Kg), not forgetting the security charges, parking and housing charges.

Recently, Airports in America have manipulated landing fees to encourage airlines to fly fewer planes or schedule landings for off-peak times or even less-busy airports, hence, the need for considering such charge when flying to US airports for long stay.

Antoinete Bruce
Senior Consultant ? Global Travels Journals Network
antoinetebruce@gmail.com

Source: http://www.modernghana.com/news/368908/1/ghana-president-pays-165000-parking-charges-on-fal.html

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Sunday, December 25, 2011

rsharp83: I'm at Wyatt Park Baptist Church (2902 N Leonard Rd, St Joseph) http://t.co/TY6gDuPr

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I'm at Wyatt Park Baptist Church (2902 N Leonard Rd, St Joseph) 4sq.com/sL1cC6 rsharp83

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Texas family rescued from snowdrift in New Mexico

ALBUQUERQUE, N.M. (AP) - Rescuers Wednesday pulled a Texas family from a car that had been buried in a snowdrift for nearly two days on a rural northeastern New Mexico highway.

State police say rescuers had to dig through four feet of ice and snow to free the Higgins family of Santa Fe, Texas, whose red Yukon got stuck on U.S. 56 near Springer when a blizzard moved through the area Monday.

Police say David and Yvonne Higgins and their 5-year-old daughter were clinging to each other and lethargic when they were found about 2:45 Wednesday morning.

The family is recovering at Miners Colfax Medical Center in Raton.

State police say they got a distress call and launched a search for the family Tuesday evening.

The Higgins were among 32 vehicles state police and guardsmen rescued from the storm, but they were the only ones who police say needed medical attention.

(Copyright 2011 The Associated Press. All rights reserved.)

Source: http://northnewmexico.kob.com/news/news/104395-texas-family-rescued-snowdrift-new-mexico

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wbaltv11: NCAA Hoops: Wagner Stuns No. 13 Pitt http://t.co/izUamLg8 http://t.co/97pzY2n3

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NCAA Hoops: Wagner Stuns No. 13 Pitt dlvr.it/11yHZC wbaltv.com wbaltv11

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Saturday, December 24, 2011

DNA mismatch repair happens only during a brief window of opportunity

Thursday, December 22, 2011

In eukaryotes ? the group of organisms that include humans ? a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells.

In a paper published in the December 23, 2011 issue of the journal Science, researchers at the Ludwig Institute for Cancer Research and the University of California, San Diego School of Medicine have solved part of the mystery of how these proteins do their job, a process called DNA mismatch repair (MMR).

"One of the major questions in MMR is how MMR proteins figure out which base in a DNA mispair is the wrong one," said Ludwig Institute assistant investigator Christopher D. Putnam, PhD, an adjunct assistant professor of medicine at UC San Diego. "For example, if guanine (G) is inappropriately in a base-pair with thymine (T), is the G or the T the error? Picking the wrong base results in mutations, not fixes."

Using Saccharomyces cerevisiae, or baker's yeast, as their model organism, the researchers, led by Richard D. Kolodner, PhD, Ludwig Institute investigator and UCSD professor of medicine and cellular and molecular medicine, discovered that newly replicated DNA produces a temporary signal for 10 to 15 minutes after replication which helps identify it as new ? and thus a potential subject for MMR.

The actual signal was not identified, but Putnam said it might be tell-tale nicks in single-stranded DNA or certain proteins associated with replication. The scientists are working to pinpoint the precise signal.

The findings, combined with earlier, published work that visualized MMR in a living cell for the first time, more fully explains how eukaryotes eliminate DNA replication errors, which can result in defects and the development of cancers.

"How eukaryotes identify the newly synthesized strand of DNA is a mystery that has persisted for at least 30 years," said Putnam. "These findings really change our ideas of how MMR works," said Putnam.

###

University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 45 time(s).

Source: http://www.labspaces.net/116283/DNA_mismatch_repair_happens_only_during_a_brief_window_of_opportunity

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RedScareBot: Smurf Communism RT @Dharma115: @mimiplush or such a useless ASS of a socialist president?

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Friday, December 23, 2011

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Thursday, December 22, 2011

320.000 Playstation Vita vendidas en tan solo dos d?as

La Playstation Vita es sin duda uno de los anuncios m?s esperados del a?o. Bueno del a?o 2011 quer?a decir para los japoneses, porque en el caso del resto del mundo, vamos a tener que esperar al a?o que viene para poder verla a la consola port?til de Sony, que seg?n ello va a cambiar nuestro modo de jugar en cualquier parte.

En todo caso, aunque nosotros no vayamos a verla antes de que den las campanadas para despedir al 2011, lo cierto es que el ?xito parece haberle llegado nada m?s salir a la Playstation Vita, porque en solo dos d?as el mercado japon?s de ha vuelto loco, y ya se han comprado nada menos que 320.000 unidades. Esto significa no solo que la consola es en realidad de lo mejorcito de la compa??a, al menos en sus inicios, si no que dentro de nada se van a quedar sin unidades.

Y es que la Playstation Vita con esas 320.000 unidades que les estamos contando, vienen a suponer la mitad de las unidades que Sony hab?a encargado para su primera tandada, por lo que el mercado japon?s de seguro que se quedar? con ganas de m?s, y habr? que esperar entonces para el 2012, Mientras tanto de seguro que las primeras opiniones van a llegar antes de que termine el a?o, y en Gizmotika, ya se las contamos, como siempre

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Source: http://www.gizmotika.com/320-000-playstation-vita-vendidas-en-tan-solo-dos-dias/

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Monday, December 19, 2011

Death or victory at the Grand Prix (The Week)

New York ? With one race left, says Michael Cannell, American Phil Hill had a shot to be the Grand Prix champion of 1961

THEY BEGAN ARRIVING a day in advance. The loyal Ferrari following ? the tifosi ? rolled up in caravans of Fiats and battered motorbikes to camp among the chestnut groves that spread more than 600 acres around the boomerang-shaped racetrack in Monza, Italy. By the glow of evening campfires they raised cups of grappa to the great drivers, the piloti who once thundered around the terrible banked turns of the Autodromo Nazionale. Most of them were gone now. Between 1957 and 1961, 20 Grand Prix drivers had died. Many more suffered terrible injuries. In the days before seat belts and roll bars, they were crushed, burned, and beheaded with unnerving regularity.

Inside the Autodromo, half a dozen teams and 32 drivers warmed up for the 267-mile Italian Grand Prix, the climactic race of the 1961 season. The spotlight was focused squarely on Ferrari teammates, drivers Phil Hill and Count Wolfgang von Trips. The next afternoon, on Sunday, Sept. 10, they would settle their long fight for the Grand Prix title, racing's highest laurel.

SEE MORE: The couple who got married while running the New York City Marathon

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Von Trips held a four-point edge ? points are awarded for first- through sixth-place finishes ? and he had earned the advantageous pole position with the fastest practice laps. Tall, blond, and blue-eyed, Von Trips was descended from German nobility, and he cut a glamorous figure even in Grand Prix circles. He had the comportment of a champion, though he had crashed so many times he was plagued with the nickname Count von Crash. Hill, a California mechanic and hot-rodder, was a solitary man, given to apprehension and self-doubts about racing. He had won at Monza a year earlier, and he had set several lap records. If Von Trips was the erratic star, Hill was his rock-steady complement. Like any great sports story, it was a pairing of opposites.

The two men had traded checkered flags all summer as the Grand Prix made its way through six European countries. Neither one was Italian, which suited Enzo Ferrari, the reclusive white-haired padrone of the Ferrari empire. Every time an Italian driver died, the government launched a meddlesome investigation and the Vatican made thunderous condemnations.

SEE MORE: Mike Krzyzewski: Greatest basketball coach ever?

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The location only heightened the suspense. The Italians called Monza the death circuit, in part because the banked turns catapulted errant cars like cannonballs. The sloped surface was coarse and pockmarked, and it exerted a centrifugal pull that the fragile Formula 1 cars were not designed to handle. More dangerous still, the long straights allowed drivers to touch 180 mph, and to slipstream inches apart. A series of tight curves, known as chicanes, had been installed to slow the cars, but it was still a track to be driven flat out.

ON A MILD and clear mid-September morning, the drivers went through their prerace routine wearing polo shirts and sunglasses. Hill asked a mechanic to splash a bucket of water on the back of his coveralls to keep him cool. Von Trips was as relaxed as ever, napping on a bench in the corner of the pits. He roused himself and ate a pear as the crew rolled his car into the pole position ? the inside slot on the front row ? marked with a white line on the gray asphalt. It was the only time that Von Trips had earned the top spot. "We may be teammates," he said of Hill as he adjusted his silver helmet, "but one has to fight. I love fighting."

SEE MORE: Albert Pujols' quarter-billion-dollar deal: 'Disaster' for the Angels?

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Everything but the fight faded in the closing moments before the start. Mechanics darted about, shouting at one another in four languages. A heaving crowd of 50,000 packed the grandstands and bleachers, pressed against wire fences at the edge of the 6.2-mile course. It was their moment to see a Ferrari renaissance, to defeat the hated Brits and their Lotus cars. The drivers emerged from the pits in Dunlop coveralls and lowered themselves one by one into their cars.

Five, four, three, two, one. The Italian flag swung down and the cars leaped. Hill's car had "a stumble to it," he said, "but when the flag dropped I was gone."

SEE MORE: The 100-year-old marathoner snubbed by Guinness World Records

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Von Trips had a history of early faltering. It often took him a lap or so to shed his jitters and find his rhythm. True to form, he missed a few beats at the start and mired himself in a pack of six cars following Hill in tight formation, moving inches apart through the broad Curva Grande and the two sharp rights at the Curva di Lesmo. Von Trips was in fourth as the group charged down the long backstretch and around the big south curve to finish the first lap.

With Hill pulling away, Von Trips surely felt an urgency to maneuver his way up through the tightly bunched field. It was still early, but if he got trapped in traffic he might forfeit his chance for a top finish, and with it his edge over Hill. With teeth bared he passed the defending world champion Jack Brabham and Lotus's Jim Clark in two powerful blasts of acceleration.

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On the second lap, Von Trips sped through a bend in the backstretch with Clark trailing behind and slightly to his left. The bend slowed them only slightly as they rolled into the fastest stretch, a straight where drivers could press the accelerator for nearly 30 full seconds. Moving at 150 mph, Von Trips watched for his chance to pass.

Four hundred feet before the next turn the German swerved left to make his move. In his haste to catch Hill, he was unaware that Clark had stayed close. He may have assumed that Clark was slipstreaming directly behind him. In any case, Von Trips "shifted sideways," Clark later said, "so that my front wheels collided with his back wheels. It was the fatal moment."

SEE MORE: The New York City Marathon: By the numbers

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VON TRIPS COMMITTED a tiny miscalculation, a miscue of no more than an inch, but at 150 mph it was enough to sling him onto a grassy shoulder to the left. His wheels plowed the soft earth, as the car rode up a 5-foot slope where spectators stood two deep behind a chest-high chicken-wire fence. In an instant of explosive violence, the Ferrari slashed along the fence for about 10 feet, shredding spectators like a big red razor, then bounced end-over-end back onto the track. The mauled car came to rest right side up with its wheels collapsed inward.

Five spectators standing along the fence died instantly, their skulls crushed by the threshing car. The survivors screamed in reaction to the death all around them. Bodies lay in scattered clumps. Ten more would die later. More than 50 were injured.

SEE MORE: The NBA lockout ends: Winners and losers

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Meanwhile, Clark's Lotus spun and struck the embankment several times before coming to a rest in the grassy stretch beside the road. The car was crushed, but Clark squirmed out unscathed.

The man who was supposed to be the Grand Prix champion lay facedown on the track in bloodied coveralls, alone and motionless. His car had rolled on top of him, then, on the next bounce, flung him like a rag doll. His distinctive silver helmet had not saved him, nor had the flimsy roll bar.

SEE MORE: Remembering Joe Frazier

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Clark jumped from his car and helped a race marshal drag Von Trips's car to the shoulder. He glanced at Von Trips, but could not bring himself to check on him. "I didn't really want to go over to where he lay," Clark said. With his helmet tucked under his arm, Clark went back to the pits, where he all but collapsed.

Von Trips had died of skull fractures by the time an ambulance arrived. In a few savage seconds, no more than a few heartbeats, all his charm and promise, all the hope he offered to his troubled homeland, came to a violent end.

SEE MORE: Labor dispute: Will the entire NBA season be lost?

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A paramedic spread a sheet over the body. A bloodied forearm dangled from the shroud as Von Trips was carried to the ambulance on a stretcher. It was the public's last glimpse of him. All over Germany people froze over their coffee or pilsner, as the radio sportscaster waited for a messenger from the Ferrari pit to explain why the count had not come around on the last lap.

Meanwhile, the race flowed on with Hill leading Moss by 18 seconds. Drivers wove through the smoke and debris, slowed by a marshal waving a flag of caution while the bloodied bodies were laid out on the roadside covered in tent canvas and newspapers. No announcement was made to the crowd.

SEE MORE: Rangers-Cardinals Game 6: 'The greatest World Series game ever'?

?

Hill passed the scene 41 more times that afternoon. On each lap he glimpsed the crumpled remains of the car, but he was uncertain whose it was until he saw Von Trips's name removed from the scoreboard.

After Von Trips crashed, three other Ferraris dropped out. Watching on television in Modena, Enzo Ferrari said, 'Abbiamo perduto.' We have lost. It was a curious reaction given that Hill was driving a nearly perfect race, a masterpiece of precision and pacing. Less than two hours after Von Trips crashed, Hill whipped by the checkered flag in first place, the only one of five Ferraris to finish.

The win gave Hill nine points, clinching the championship. He had overcome waves of obstacles ? Ferrari's partisanship, a late-summer deficit in points, an 11th-hour engine failure ? to become the first American to win racing's greatest prize. Among other things, the win resolved the tug-of-war between anguish and ambition that had gripped him for more than a decade. It affirmed a pursuit that he had so often doubted.

Hill had arrived at the triumphant moment that had drawn him since childhood like a distant light. The realization that he had prevailed ? the wondrous reality of it ? came over him that day as "a warming relief, a soaring feeling."

Hill walked to the victory podium in a throng of pushing, swaying well-wishers. Sweat matted his hair and goggles dangled from his neck. He sipped from a bottle of mineral water and asked about Von Trips. "I suspected the worst, but it was not until after champagne and congratulations on the victory stand that I was told," he said later.
?

Sports Illustrated reported that Hill sobbed and dashed away as the flashbulbs popped. But he was too inured for that. Hill may have sagged. He may have paled beneath his sooty cheeks. But his face betrayed nothing but stony acceptance. "At the risk of seeming to be callous I can only say that my emotional defenses are pretty strong," he later wrote.

Von Trips claimed all the morning headlines. The newspapers buried Hill's triumph, if they mentioned it at all. The insinuation was that Von Trips was the rightful winner. Hill was merely an understudy, despite two first-place finishes, two seconds, and two thirds. The New York Times printed an account of Von Trips' death on its front page. Mention of the new champion waited until after the story jumped to page 33. "He knows that his victory has been so submerged in the press under the death toll," the reporter wrote, "that few people even realize he is champion."



?2011 by Michael Cannell, reprinted courtesy of Twelve. Excerpted from The Limit: Life and Death on the 1961 Grand Prix Circuit.

?

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    Source: http://us.rd.yahoo.com/dailynews/rss/oped/*http%3A//news.yahoo.com/s/theweek/20111216/cm_theweek/222546

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    Sunday, December 18, 2011

    Inflation eases, creates space for Fed stimulus (Reuters)

    WASHINGTON (Reuters) ? Consumer prices were flat in November as Americans paid less for cars and gasoline, a further sign of a cooldown in inflation that could give the Federal Reserve more room to help a still weak economy.

    The Labor Department said on Friday the Consumer Price Index was unchanged last month. Economists had expected an increase of 0.1 percent.

    Prices spiked earlier in the year, but the report showed the trend has shifted. Over the past 12 months, prices have risen 3.4 percent. That marked a second monthly decline from a three-year high in September.

    The report "leaves the Fed ample cover for any additional monetary policy accommodation they may see warranted in the New Year," said Ian Lyngen, a bond strategist at CRT Capital Group in Stamford, Connecticut.

    Still, some of the data could give pause to policymakers at the central bank.

    Outside food and energy, prices climbed a faster-than-expected 0.2 percent. These so-called core prices rose 2.2 percent in the 12 months through November, up from 2.1 percent in October.

    "Core inflation ... is a bit more persistent than what some people had expected," said Jeremy Lawson, an economist at BNP Paribas in New York.

    Economists polled by Reuters this week saw inflation slowing to 2.6 percent during the first quarter of next year, which could help convince the Fed to do more to bring down the country's 8.6 percent unemployment rate.

    Prices for U.S. government debt rose slightly on Friday as investors saw the data opening the door a bit wider to Fed stimulus. U.S. stocks rose and the dollar fell against the euro as investors remained on edge over the euro zone's debt crisis.

    The U.S. recovery has picked up momentum over the past few months, but the Fed on Tuesday warned about turmoil in financial markets abroad and it kept the option of further monetary action on the table.

    FED EASE STILL IN PLAY

    In an appearance before Congress on Friday, New York Federal Reserve Bank President William Dudley warned that a worsening of Europe's sovereign debt crisis could hit U.S. banks, potentially tightening credit for households and businesses.

    "Europe's problems are a serious risk for the U.S. economic outlook," he said.

    In recent months, cooling gasoline prices have left more money for consumers to spend on other things, helping the economy gain some steam. In November alone, gasoline prices fell 2.4 percent.

    The effects of Japan's earthquake disaster in March, which disrupted global supply chains and pushed auto prices higher earlier in the year, are also subsiding. Prices for new vehicles fell 0.3 percent in November.

    Prices for food rose 0.1 percent. Within the core index, prices for apparel jumped 0.6 percent , but the increase in the department's main gauge of homeownership costs cooled to 0.1 percent from 0.2 percent in October.

    Many economists have said the Fed might try to give the economy a bit of help at a meeting on January 24-25 by laying out forecasts for interest rates that could underscore its willingness to keep borrowing costs ultra-low for a prolonged period.

    The U.S. central bank has held overnight interest rates near zero since December 2008 and has bought $2.3 trillion in government and mortgage-related bonds in a further attempt to stimulate a robust recovery.

    Fed watchers also think the U.S. central bank could step up bond buying later in 2012. A Reuters poll on Tuesday found most Wall Street economists think the central bank will undertake a new program of buying mortgage-backed securities.

    (Additional reporting by Chris Reese and Richard Leong in New York; Editing by Neil Stempleman, Andrew Hay; and Jan Paschal)

    Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20111216/bs_nm/us_economy

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    Saturday, December 17, 2011

    Overstock.com unloads goods at Utah auction

    Craig Slack looks over pallets of returned goods before the bidding begins at Overstock.com's warehouse, Thursday, Dec. 15, 2011,?in Salt Lake City. Over 600 people registered to bid on pallets of returned items during the company's first auction of this kind. (AP Photo/Jim Urquhart)

    Craig Slack looks over pallets of returned goods before the bidding begins at Overstock.com's warehouse, Thursday, Dec. 15, 2011,?in Salt Lake City. Over 600 people registered to bid on pallets of returned items during the company's first auction of this kind. (AP Photo/Jim Urquhart)

    Joyce Brocco and her husband Ed Brocco look over pallets of returned goods before the bidding begins at Overstock.com's warehouse, Thursday, Dec. 15, 2011,?in Salt Lake City. Over 600 people registered to bid on pallets of returned items during the company's first auction of this kind. (AP Photo/Jim Urquhart)

    Auctioneer Rob Olson runs the auction at Overstock.com's warehouse, Thursday, Dec. 15, 2011,?in Salt Lake City. Over 600 people registered to bid on pallets of returned items during the company's first auction of this kind. (AP Photo/Jim Urquhart)

    Karl Fackrell makes a bid during an auction at Overstock.com's warehouse, Thursday, Dec. 15, 2011,?in Salt Lake City. Over 600 people registered to bid on pallets of returned items during the company's first auction of this kind. (AP Photo/Jim Urquhart)

    Jan Miller and her husband Larry Miller look over pallets of returned goods before bidding during an auction at Overstock.com's warehouse, Thursday, Dec. 15, 2011,?in Salt Lake City. Over 600 people registered to bid on pallets of returned items during the company's first auction of this kind. (AP Photo/Jim Urquhart)

    (AP) ? Overstock.com, the online retailer known for selling distressed merchandise, was feeling a little distressed itself. With household merchandise stacking up in a warehouse, it opened the doors Thursday for an auction of goods assembled hodgepodge that had to be bought together on pallets.

    Overstock was overstocked.

    "We call it revenue recovery," said Carroll Morale, a vice president of supply chain, who said Overstock had already written off the mostly returned goods as a loss and was happy to get anything back.

    More than 600 people registered for the warehouse auction, and many said they were bidding blindly because pallets were shrink-wrapped in black plastic and they didn't study the manifests.

    "I just came to blow some money ? my wife is going to kill me," said Joseph Kikel, a 34-year-old car salesman who bought a pallet of furniture for about 25 cents on the dollar.

    The man from Layton, Utah, spent $350 for a leather chair, a dresser, an entertainment center and padded bench. He wasn't certain what he bought until he unloaded boxes in his pickup.

    It was Overstock's first auction and to mix things up, workers stacked pallets with whatever moved down a conveyor belt ? "you could get dinnerware with luggage," Morale said.

    Salt Lake City auctioneer Rob Olson said 307 pallets of goods were sold for around $150,000.

    "It was crazy," he said. The auction's final pallet contained $14,000 worth of women's dresses, he said. It sold for $1,800.

    Normally Overstock arranges sales of unsold goods privately to other liquidators. The company called the auction a community service, and said it was able to empty part of its sprawling warehouse for expected holiday merchandise returns.

    "A lot of it is furniture and d?cor, but one of my lots had a laptop," said Karl Fackrell, a 65-year-old real-estate developer in South Jordan, Utah.

    Fackrell said he paid about $2,500 ? or about 20 cents on the dollar ? for six pallets of goods. "I'll sell the stuff I don't want," he said.

    The auction was the latest innovation from a company whose innovations sometimes backfire.

    Overstock "shot itself in the foot" earlier this year with a rebranding campaign as "O.co" that only confused consumers, said Daniel Kurnos, a stock analyst with The Benchmark Co.

    Overstock was penalized earlier this year for setting up fake websites that linked to its own website, Google has said. During the two-month penalty time, Google pushed Overstock further down in search results. Overstock has said its revenue dropped 5 percent as a result.

    And in California, the company's efforts to avoid charging sales tax forced it to cut ties with merchandisers who generated 5 percent of Overstock's revenue, he said.

    Overstock reported a loss of $16 million for the first nine months of 2011, compared with a loss of $1 million in 2010. The company has generated profits in only two of its dozen years in business as it tries to compete in a crowded field of Internet liquidators.

    "They're expecting growth for the holiday quarter, but they have to dig themselves out of a hole," Kurnos said.

    Overstock says things are looking up ? Cyber Monday sales after Thanksgiving weekend were the largest ever for the company. The company once aspired to take on Internet goliaths, but competitors Amazon and eBay generate sales 30 or more times greater.

    On Thursday, some Utah consumers were just happy to grab a quick deal and unwrap it at home.

    Others who described themselves as more serious bidders were holding onto their wallets until the end of the one-day auction, when they hoped to pick up stuff for pennies on the dollar.

    Douglas Larson, a home renovator looking for furniture, was unimpressed by Overstock's emphasis on the full retail value of goods.

    Nobody pays full retail, he sniffed.

    "So you cut that in half right away, then cut it in half again," he said.

    That was his bidding strategy, but he complained he couldn't inspect any of the shrink-wrapped boxes of goods.

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2011-12-16-US-Overstock-Overstocked/id-b0ab12b3d74e42bf9e06dcc0ac0bd26e

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    Census shows 1 in 2 people are poor or low-income

    Chart shows the percentage of people by ratio of Income and resources to poverty threshold

    Chart shows the percentage of people by ratio of Income and resources to poverty threshold

    (AP) ? Squeezed by rising living costs, a record number of Americans ? nearly 1 in 2 ? have fallen into poverty or are scraping by on earnings that classify them as low income.

    The latest census data depict a middle class that's shrinking as unemployment stays high and the government's safety net frays. The new numbers follow years of stagnating wages for the middle class that have hurt millions of workers and families.

    "Safety net programs such as food stamps and tax credits kept poverty from rising even higher in 2010, but for many low-income families with work-related and medical expenses, they are considered too 'rich' to qualify," said Sheldon Danziger, a University of Michigan public policy professor who specializes in poverty.

    "The reality is that prospects for the poor and the near poor are dismal," he said. "If Congress and the states make further cuts, we can expect the number of poor and low-income families to rise for the next several years."

    Congressional Republicans and Democrats are sparring over legislation that would renew a Social Security payroll tax cut, part of a year-end political showdown over economic priorities that could also trim unemployment benefits, freeze federal pay and reduce entitlement spending.

    Robert Rector, a senior research fellow at the conservative Heritage Foundation, questioned whether some people classified as poor or low-income actually suffer material hardship. He said that while safety-net programs have helped many Americans, they have gone too far, citing poor people who live in decent-size homes, drive cars and own wide-screen TVs.

    "There's no doubt the recession has thrown a lot of people out of work and incomes have fallen," Rector said. "As we come out of recession, it will be important that these programs promote self-sufficiency rather than dependence and encourage people to look for work."

    Mayors in 29 cities say more than 1 in 4 people needing emergency food assistance did not receive it. Many middle-class Americans are dropping below the low-income threshold ? roughly $45,000 for a family of four ? because of pay cuts, a forced reduction of work hours or a spouse losing a job. Housing and child-care costs are consuming up to half of a family's income.

    States in the South and West had the highest shares of low-income families, including Arizona, New Mexico and South Carolina, which have scaled back or eliminated aid programs for the needy. By raw numbers, such families were most numerous in California and Texas, each with more than 1 million.

    The struggling Americans include Zenobia Bechtol, 18, in Austin, Texas, who earns minimum wage as a part-time pizza delivery driver. Bechtol and her 7-month-old baby were recently evicted from their bedbug-infested apartment after her boyfriend, an electrician, lost his job in the sluggish economy.

    After an 18-month job search, Bechtol's boyfriend now works as a waiter and the family of three is temporarily living with her mother.

    "We're paying my mom $200 a month for rent, and after diapers and formula and gas for work, we barely have enough money to spend," said Bechtol, a high school graduate who wants to go to college. "If it weren't for food stamps and other government money for families who need help, we wouldn't have been able to survive."

    About 97.3 million Americans fall into a low-income category, commonly defined as those earning between 100 and 199 percent of the poverty level, based on a new supplemental measure by the Census Bureau that is designed to provide a fuller picture of poverty. Together with the 49.1 million who fall below the poverty line and are counted as poor, they number 146.4 million, or 48 percent of the U.S. population. That's up by 4 million from 2009, the earliest numbers for the newly developed poverty measure.

    The new measure of poverty takes into account medical, commuting and other living costs. Doing that helped push the number of people below 200 percent of the poverty level up from 104 million, or 1 in 3 Americans, that was officially reported in September.

    Broken down by age, children were most likely to be poor or low-income ? about 57 percent ? followed by seniors over 65. By race and ethnicity, Hispanics topped the list at 73 percent, followed by blacks, Asians and non-Hispanic whites.

    Even by traditional measures, many working families are hurting.

    Following the recession that began in late 2007, the share of working families who are low income has risen for three straight years to 31.2 percent, or 10.2 million. That proportion is the highest in at least a decade, up from 27 percent in 2002, according to a new analysis by the Working Poor Families Project and the Population Reference Bureau, a nonprofit research group based in Washington.

    Among low-income families, about one-third were considered poor while the remainder ? 6.9 million ? earned income just above the poverty line. Many states phase out eligibility for food stamps, Medicaid, tax credit and other government aid programs for low-income Americans as they approach 200 percent of the poverty level.

    The majority of low-income families ? 62 percent ? spent more than one-third of their earnings on housing, surpassing a common guideline for what is considered affordable. By some census surveys, child-care costs consume close to another one-fifth.

    Paychecks for low-income families are shrinking. The inflation-adjusted average earnings for the bottom 20 percent of families have fallen from $16,788 in 1979 to just under $15,000, and earnings for the next 20 percent have remained flat at $37,000. In contrast, higher-income brackets had significant wage growth since 1979, with earnings for the top 5 percent of families climbing 64 percent to more than $313,000.

    A survey of 29 cities conducted by the U.S. Conference of Mayors being released Thursday points to a gloomy outlook for those on the lower end of the income scale.

    Many mayors cited the challenges of meeting increased demands for food assistance, expressing particular concern about possible cuts to federal programs such as food stamps and WIC, which assists low-income pregnant women and mothers. Unemployment led the list of causes of hunger in cities, followed by poverty, low wages and high housing costs.

    Across the 29 cities, about 27 percent of people needing emergency food aid did not receive it. Kansas City, Mo., Nashville, Tenn., Sacramento, Calif., and Trenton, N.J., were among the cities that pointed to increases in the cost of food and declining food donations, while Mayor Michael McGinn in Seattle cited an unexpected spike in food requests from immigrants and refugees, particularly from Somalia, Burma and Bhutan.

    Among those requesting emergency food assistance, 51 percent were in families, 26 percent were employed, 19 percent were elderly and 11 percent were homeless.

    "People who never thought they would need food are in need of help," said Mayor Sly James of Kansas City, Mo., who co-chairs a mayors' task force on hunger and homelessness.

    ___

    Online:

    Census Bureau: www.census.gov

    U.S. Conference of Mayors: www.usmayors.org/

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-12-15-Low%20Income%20America/id-bad007531a194408a6d60b504b92959c

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    Journey with Taliban shows militants' resilience (AP)

    SOUTH WAZIRISTAN, Pakistan ? For 15 hours, we walked with Taliban fighters through territory supposedly controlled by the Pakistani army and frequently pounded by U.S. drone strikes. Avoiding roads and towns, we easily evaded soldiers and were shown recruits drilling with weapons, militant positions and ? from a distance ? a compound used by foreign fighters.

    The rare trip to South Waziristan revealed the resilience of militants in the northwestern tribal areas, some of whom are also battling American soldiers across the frontier in Afghanistan. It also demonstrated that the insurgents, who once ruled much of South Waziristan from permanent bases with many hundreds of fighters, are now largely a guerrilla force there.

    ___

    EDITOR'S NOTE: Associated Press reporter, photographer and videographer Ishtiaq Mahsud spent six days with fighters from the Pakistani Taliban close to the Afghan border. His account of their travels through South Waziristan offers a look at an area that the Pakistani military claimed had been brought under control after an army offensive two years ago.

    ___

    The Pakistani Taliban had invited three Pakistani journalists to meet its leader, Hakimullah Mehsud, at a time when splits have appeared in the movement. But Mehsud canceled, with his aides saying he was called into urgent meetings with a delegation of Afghan Taliban elders who had arrived from across the border.

    The trip began in the capital of North Waziristan, Miran Shah, where the Pakistan army has yet to launch an offensive despite requests from Washington. Militants, including al-Qaida and Afghan Taliban factions, are in firmer control in this region than in South Waziristan. Extremists from other countries and other areas of Pakistan were visible on the streets of the town.

    We then drove to the boundary with the south, and began our journey on foot, accompanied by four fighters.

    South Waziristan was once home to about 500,000 people but its towns and villages are now mostly empty. The population was told to flee ahead of a major Pakistani army offensive in 2009. The army has declared victory, but most locals haven't returned. They do not believe official statements that their homeland is safe.

    In one abandoned village, three men were living in a single room in a ruined house. They said they couldn't leave because they had no money and two of them were blind from birth. Their sole possessions were a dirty mat and some blackened cooking pots. One, 30-year-old Mafiq, said the Taliban gave them monthly rations and sometimes cooked food.

    At night, we slept in empty houses. Once, we feasted on goat with about 40 fighters in a forest encampment.

    The Pakistani military remains in South Waziristan in force but its men are often targeted in ambushes.

    On the main roads there were army posts, vital for supplying the roughly 30,000 soldiers in the region. But it was easy to travel without being spotted or pursued so long as our group stayed off them.

    "The army is confined to the roads," said Shameem Mehsud, the operational commander of the Pakistani Taliban. "All the surrounding areas are in Taliban control."

    After 15 hours hiking, our group came to a semi-permanent forward position used to attack troops traveling on a main road below. About 30 fighters were armed with rocket launchers, sniper rifles and artillery. Through binoculars, Mehsud pointed out what appeared to be an anti-aircraft gun on a nearby ridge he said belonged to the Taliban.

    As we chatted, the army fired mortars at the position, one round landing about 50 meters (yards) away.

    On the return journey to the north, again on foot but using a different route, one of the fighters pointed to a collection of buildings that he said was used by fighters from Turkmenistan. He said fighters from other countries stayed at different places in the region.

    The tribal regions, particularly North Waziristan, have become a magnet for Muslims wanting to fight jihad or "holy war." The area is also used by Afghan militants to stage attacks inside their homeland, knowing that U.S. and NATO troops cannot enter Pakistani territory.

    The Pakistani army, which has several times flown reporters to South Waziristan and other Afghan border areas to show off its achievements against militants, was not available for comment on what we observed on our trip.

    The army offensive in South Waziristan was launched after heavy American pressure, and was followed by operations in six of the seven tribal regions along the border. But as U.S.-led forces have found in Afghanistan, holding exposed and remote territory against insurgents who know the area and can count on local support is fiendishly difficult.

    Eager to wipe out a safe haven for al-Qaida and protect American troops in Afghanistan, the United States has supplied Pakistan with money, weapons and expert assistance for its campaign against the militants. That cooperation has faltered badly this year amid a series of crises between the two nations, whose divergent interests in Afghanistan have proven hard to reconcile.

    There is no love lost between the Pakistani military and the Pakistani Taliban, which is allied to al-Qaida and has carried out scores of suicide bombings around the country since 2007.

    Some insurgent commanders in the northwest have said recently they were in peace negotiations with the Pakistani government. Militant attacks in major cities outside the northwest have been down sharply this year, a drop some have attributed to the success of army operations and the drone strikes.

    The commanders in South Waziristan rejected any talk of peace. They said they would negotiate with the government only if Islamic law were implemented throughout the country, the army withdraws from the region and all Taliban prisoners are released.

    "Despite all their resources and atomic power, America, NATO and Pakistan cannot defeat the Taliban as our suicide bombers will use their bones as bullets, their flesh as gunpowder and their blood as fuel," Mehsud said. "They have no way to counter to this spirit."

    Pakistan's spy agency has been accused of aiding other militants, such as the Haqqanis and other factions in the Afghan Taliban who carry out attacks on U.S. troops across the border.

    CIA drones, in turn, have targeted militants with missile strikes in the Pakistani tribal regions.

    Although Mehsud said the militants often changed their training grounds because of fear of attack by American drones, he and his fighters didn't appear overly concerned about the missiles. There have been more than 60 such attacks this year, the vast majority in the Waziristans.

    At one point on the trip, the militants showed us young recruits ? they called them trainee suicide bombers ? exercising on a flat piece of land in a deserted village surrounded by mountains. Wearing masks, they staged the mock capture of a man wearing the uniform of a Pakistani soldier.

    "We will jump in the fire without any hesitation on the orders of our commander," they shouted in unison at the end.

    Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111214/ap_on_re_as/as_pakistan_walk_with_the_taliban

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    Friday, December 16, 2011

    Alzheimer's drug candidate may be first to prevent disease progression, mouse study suggests

    ScienceDaily (Dec. 14, 2011) ? A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published in PLoS ONE.

    When given to mice with Alzheimer's, the drug, known as J147, improved memory and prevented brain damage caused by the disease. The new compound, developed by scientists at the Salk Institute for Biological Studies, could be tested for treatment of the disease in humans in the near future.

    "J147 enhances memory in both normal and Alzheimer's mice and also protects the brain from the loss of synaptic connections," says David Schubert, the head of Salk's Cellular Neurobiology Laboratory, whose team developed the new drug. "No drugs on the market for Alzheimer's have both of these properties."

    Although it is yet unknown whether the compound will prove safe and effective in humans, the Salk researchers' say their results suggest the drug may hold potential for treatment of people with Alzheimer's.

    As many as 5.4 million Americans suffer from Alzheimer's, according to the National Institutes of Health. More than 16 million will have the disease by 2050, according to Alzheimer's Association estimates, resulting in medical costs of over $1 trillion per year.

    The disease causes a steady, irreversible decline in brain function, erasing a person's memory and ability to think clearly until they are unable to perform simple tasks such as eating and talking, and it is ultimately fatal. Alzheimer's is linked to aging and typically appears after age 60, although a small percentage of families carry a genetic risk for earlier onset. Among the top ten causes of death, Alzheimer's is the only one without a way to prevent, cure or slow down disease progression.

    Scientists are unclear what causes Alzheimer's, which appears to emerge from a complex mix of genetics, environment and lifestyle factors. So far, the drugs developed to treat the disease, such as Aricept, Razadyne and Exelon, only produce fleeting memory improvements and do nothing to slow the overall course of the disease.

    To find a new type of drug, Schubert and his colleagues bucked the trend within the pharmaceutical industry of focusing exclusively on the biological pathways involved in the formation of amyloid plaques, the dense deposits of protein that characterize the disease. To date, Schubert says, all amyloid-based drugs have failed in clinical trials.

    Instead, the Salk team developed methods for using living neurons grown in laboratory dishes to test whether or not new synthetic compounds were effective at protecting the brain cells against several pathologies associated with brain aging. Based on the test results from each chemical iteration of the lead compound, which was originally developed for treatment of stroke and traumatic brain injury, they were able to alter its chemical structure to make a much more potent Alzheimer's drug.

    "Alzheimer's is a complex disease, but most drug development in the pharmaceutical world has focused on a single aspect of the disease--the amyloid pathway," says Marguerite Prior, a research associate in Schubert's lab, who led the project along with Qi Chen, a former Salk postdoctoral researcher. "In contrast, by testing these compounds in living cell cultures, we can determine what they do against a range of age-related problems and select the best candidate that addresses multiple aspects of the disease, not just one."

    With a promising compound in hand, the researchers shifted to testing J147 as an oral medication in mice. Working with Amanda Roberts, a professor of molecular neurosciences at The Scripps Research Institute, they conducted a range of behavioral tests that showed that the drug improved memory in normal rodents.

    The Salk researchers went on to show that it prevented cognitive decline in animals with Alzheimer's and that mice and rats treated with the drug produced more of a protein called brain-derived neurotrophic factor (BDNF), a molecule that protects neurons from toxic insults, helps new neurons grow and connect with other brain cells, and is involved in memory formation.

    Because of the broad ability of J147 to protect nerve cells, the researchers believe that it may also be effective for treating other neurological disorders, such as Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis (ALS), as well as stroke.

    The research was funded by the Fritz B. Burns Foundation, the National Institutes of Health, the Bundy Foundation and the Alzheimer's Association.

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    Story Source:

    The above story is reprinted from materials provided by Salk Institute.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Qi Chen, Marguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, C?dric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, David Schubert. A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease. PLoS ONE, 2011; 6 (12): e27865 DOI: 10.1371/journal.pone.0027865

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/TfNPBEg83ak/111214162108.htm

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    CA-CANADA Summary (Reuters)

    Canada, out of Kyoto, must still cut emissions: U.N.

    LONDON (Reuters) ? Canada still has a legal obligation under U.N. rules to cut its emissions despite the country's pullout from the Kyoto Protocol, the U.N. climate chief said Tuesday. Christiana Figueres also said the timing of Canada's move, a day after a deal to extend it was clinched at a U.N. summit in South Africa, was both regrettable and surprising.

    Analysis: Canada's Kyoto withdrawal began when Bush bolted

    OTTAWA (Reuters) - Canada's widely criticized withdrawal from the Kyoto protocol ends a decade-long saga that began in earnest when former President George W. Bush walked away from the global climate change treaty in 2001. The close links between the two economies, and the fact the United States has a population almost 10 times larger than that of Canada, meant that Ottawa ultimately felt it had to follow Washington's lead and ignore the diplomatic fallout.

    Canada pension deficit understated, think tank says

    TORONTO (Reuters) - Canada's unfunded employee pension obligations are C$80 billion ($77.7 billion) more than the federal government has previously revealed, according to a report from a high-profile think tank. The market-friendly C.D. Howe Institute said on Tuesday that liabilities for federal government pension plans total C$227 billion, far more than expected in a recent official update.

    Analysis: Canada grain sector wary of Wheat Board battle

    WINNIPEG, Manitoba (Reuters) - A wary Canadian grain industry will ease cautiously into signing forward price contracts for the prized 2012 wheat and barley crops, as legal entanglements over Ottawa's plan to end the Wheat Board's marketing monopoly hamper any swift moves into an open market. A Conservative government bill is set to end the Canadian Wheat Board's monopoly on western wheat and barley sales next August. The change would shake up the industry, creating an open market and leaving the CWB a smaller, optional grain buyer.

    Class of 2012 faces frozen hiring, study shows

    TORONTO (Reuters) - Students graduating from Canadian colleges and universities next year will face the same stagnant job market that has confronted 2011 graduates, a study released on Tuesday said. The annual report of the Canadian Association of Career Educators and Employers (CACEE) also found that while many industries have halted employment growth or are cutting jobs, others complain they can't find the people they need. Specifically, the mining and telecommunications industries say there is a shortage of graduates that have the required skills.

    Government bans veils during citizenship ceremonies

    OTTAWA (Reuters) - In a move likely to increase tension with Canada's Muslim minority, the government said on Monday it would bar all women wearing face coverings from taking part in citizenship ceremonies. Immigration Minister Jason Kenney said he had received complaints from citizenship judges and parliamentarians about veiled women taking the oath to formally become Canadian.

    Watchdog, Ottawa differ on Canada's budget balance

    OTTAWA (Reuters) - Canada's budget watchdog sees the federal government's structural balance as at least C$10 billion ($9.71 billion) lower per year than Ottawa estimates, and called for more disclosure of assumptions and methodology used in drafting forecasts. The Parliamentary Budget Officer said the discrepancy was likely caused by different estimates on how the economy is performing at any given time in relation to its potential to grow. Miscalculations can lead to bad policy decisions, it suggested.

    Crosby out indefinitely with concussion-like symptoms

    (Reuters) - Pittsburgh Penguins captain Sidney Crosby is out indefinitely with concussion-like symptoms and there is no timetable for his return, the National Hockey League's (NHL) biggest drawing card said on Monday. Crosby, who missed the last two games as a precaution, did not practice with his team on Monday and told reporters after that he has had symptoms for the last couple days.

    CN Rail, union reach tentative deal

    (Reuters) - Canadian National Railway Co and Teamsters Canada Rail Conference (TCRC) have reached a tentative agreement on labor contracts before the expiry of the current contract. Details were not available, as the agreement needs to be ratified by TCRC members, a process expected to take about 60 days.

    Congress cannot accelerate Keystone decision: State Department

    WASHINGTON (Reuters) - The U.S. State Department warned on Monday that a plan by congressional Republicans to fast track the Canada-to-Texas Keystone XL pipeline decision would violate environmental laws and force it to withhold approval. "Should Congress impose an arbitrary deadline for the permit decision ... the department would be unable to make a determination to issue a permit for this project," the State Department said in a statement.

    Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20111213/wl_canada_nm/canada_summary

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    Wednesday, December 7, 2011

    Iowa Caucus Victory Doesn???t Necessarily Secure GOP Nomination (ContributorNetwork)

    The Iowa caucus is one month away. Republican candidates for president will begin to discern how much voters approve of them Jan. 3, when Iowans choose their candidate for the GOP nominee. The Hill reports the GOP field is wide open. Newt Gingrich is moving up in the polls. Herman Cain is in crisis mode as he suspended his campaign amid allegations of an extramarital affair. Mitt Romney is trying to be victorious in Iowa where he hasn't been successful in the past.

    Even if a surprise candidate wins the Iowa caucus, it's doesn't necessarily mean that person will be the Republican nominee. History isn't necessarily on the winning candidate's side.

    * The Des Moines Register lists results of past caucuses. Republicans released numbers going back to 1980. A summary was only available for 1976.

    * In the 1980 Iowa caucus, George Bush defeated Ronald Reagan by over 2,000 votes for the GOP choice. Reagan went on to win the Republican nomination and then the presidency with Bush as his running mate for vice president. Future candidate Bob Dole only got 1,576 votes at just 1.5 percent.

    * Eight years later, Kansas Sen. Bob Dole received over 40,000 votes in the Iowa caucus on his way to a bid for the presidency. Bush came in third place with half as many votes yet he went on to win the 1988 general election over Michael Dukakis, according to the U.S. Election Atlas.

    * The 1996 Iowa caucus actually got the GOP nominee correct. Dole received the overall nomination in a crowded field of nine candidates vying for votes in the "first in the nation" election. Dole won narrowly over Pat Buchanan by less than 3,000 votes.

    * George W. Bush won the Iowa caucus in 2000 by a full 11 percentage points. Sen. John McCain came in fifth place with just over 4,000 votes.

    * The New York Times reports the 2008 Iowa caucus was one of the more interesting in history. Former Arkansas governor Mike Huckabee got over 40,000 votes while his closest competition received 29,949 votes. Romney, the current front runner, was the one who got second. McCain was the future nominee but voters wouldn't know it by his showing in Iowa. Then-Sen. Barack Obama's opponent came in a distant fourth place with just over 15,500 votes.

    Even though Iowa is first in the nation when it comes to picking presidential nominees for elections, winning the Iowa caucus doesn't guarantee success nationally. Perhaps both Romney and Gingrich should realize that as they try to win the day on Jan. 3.

    William Browning is a research librarian specializing in U.S. politics. Born in St. Louis, Browning is active in local politics and served as a campaign volunteer for President Barack Obama and Missouri Sen. Claire McCaskill.

    Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ac/20111204/pl_ac/10592215_iowa_caucus_victory_doesnt_necessarily_secure_gop_nomination

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